Sean discovers some troubling news about his daughter, Annie, who is in town visiting. Sean and Teddy make a surprising announcement. A furious Liz confronts Christian and offers Kimber unsolicited advice about him. Christian and Kimber begin a joint business venture to alleviate financial strains. Sean makes unusual attempts to battle his insomnia. Meanwhile, Sean remains distant from Teddy despite their seemingly flourishing relationship.
Liz receives life-altering news, and Matt and Kimber seek new, separate career paths with mixed results. In the sixth season premiere, Sean and Christian struggle to keep McNamara/Troy thriving in a failing economy, and enlist another surgeon to attain additional income.